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Weinshilboum, John R. Hawse, Thomas C. Spelsberg, and Matthew P. Journal of Clinical Oncology , Flockhart. Tamoxifen's selective estrogen activation effects can cause some serious side effects, including blood clots , stroke , and endometrial cancer.

If you and your doctor are considering tamoxifen as part of your treatment plan, tell your doctor if you smoke or have a history of blood clots or heart attack. If you're taking tamoxifen, call your doctor immediately if you have any of these symptoms:.

Hot flashes or night sweats from taking tamoxifen can be troubling. But a British study suggests that women who experienced hot flashes and night sweats while taking hormonal therapy medicine were less likely to have the breast cancer come back recur. Knowing that this side effect might indicate a reduced risk of the cancer coming back may help some people stick with treatment despite the side effects. Some women on tamoxifen have reported memory problems while taking the medicine.

While no definitive results are available yet, the ongoing Co-STAR Cognition in the Study of Tamoxifen and Raloxifene trial is looking at the effects tamoxifen and raloxifene have on memory and thinking. While costs vary, tamoxifen is usually less expensive than an aromatase inhibitor because it is a generic medicine. If you have health insurance, check with your insurance company to see if and how much of the cost of tamoxifen is covered.

If you don't have health insurance or your insurance doesn't cover the cost of tamoxifen, ask your doctor or nurse about programs in your area that may be able to help. Soltamox is available to patients who qualify at the same co-pay cost as generic tamoxifen. You can also read Breastcancer. Create a profile for better recommendations.

Breast implant illness BII is a term that some women and doctors use to refer to a wide range Sign up for emails about breast cancer news, virtual events, and more. Subscribe to our podcast for conversations on the issues that matter most. Join our online community to connect, share, and find peer support. Cell with estrogen receptors blocked by tamoxifen and helper proteins Larger Version.

Was this article helpful? Can we help guide you? How does this work? Learn more. A rare, but serious side effect of tamoxifen can be the development of uterine cancer.

Women who have not had a hysterectomy should have regular pap smears and gyn examinations. Abnormal vaginal bleeding should be reported to your health care provider. Your fertility, meaning your ability to conceive or father a child, may be affected by tamoxifen. Please discuss this issue with your health care provider. Not all side effects are listed above.

However, you should always inform your health care provider if you experience any unusual symptoms. Seek emergency help immediately and notify your health care provider, it you experience the following symptoms:. The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:. Always inform your health care provider if you experience any unusual symptoms.

You will be checked regularly by your health care professional while you are taking tamoxifen, to monitor side effects and check your response to therapy.

Periodic blood work to monitor your complete blood count CBC as well as the function of other organs such as your kidneys and liver may also be ordered by your doctor. Women will need a gynecologic GYN examination before therapy, and during therapy, at regular intervals.

Discuss the appropriate schedule with your health care provider. Hormones are chemical substances that are produced by glands in the body, which enter the bloodstream and cause effects in other tissues. For example, the hormone testosterone, made in the testicles and is responsible for male characteristics such as deepening voice and increased body hair. The use of hormone therapy to treat cancer is based on the observation that receptors for specific hormones that are needed for cell growth are on the surface of some tumor cells.